The human pituitary gland normally releases HGH in small bursts (pulses) throughout the day. The release of HGH is controlled primarily by two hormones released by your hypothalamus: growth hormone-releasing hormone (GHRH), which stimulates HGH release, and somatostatin, which inhibits (blocks) HGH release.
Various other endocrine hormones also regulate HGH, including insulin-like growth factor 1(IGF-1). IGF-1 is an important suppressor of GH production, while thyroxine, glucocorticoids, and ghrelin stimulate HGH production.
The IGF-1 released by your liver is one of the best effects of HGH activity. IGF-1 plays an important role in inhibiting (preventing) the release of HGH through a negative feedback loop by stimulating somatostatin and inhibiting GHRH release. However, HGH and IGF-1 secretion are regulated by each other, where HGH triggers IGF-1 release and IGF-1 inhibits HGH release in a feedback loop. In healthy people, Human Growth Hormone release is inhibited by hyperglycemia (high blood sugar) and stimulated by sleep, stress, exercise, hypoglycemia (low blood sugar), and amino acids.
The Function of human growth hormone (HGH)?
Human growth hormone has two main functions: stimulating growth (primarily in children) and affecting metabolism (how your body turns the food you eat into energy).
HGH and Growth
Human growth hormone triggers growth in almost every tissue and organ in your body. However, it is most famous for its growth-promoting effects on cartilage and bone, especially during puberty and adolescence. Cells in cartilage called chondrocytes and cells in bones called osteoblasts receive signals from HGH to increase replication and thus allow growth in size.
Once the growth plates have attached to the baby’s bones, HGH no longer increases height. Instead, HGH helps maintain normal body composition throughout your life.
HGH and Metabolism
Metabolism involves the chemical reactions that occur in your body that turn the food you eat into energy. All the cells in your body need energy to function properly. Metabolism involves many different complex processes.
HGH affects metabolism primarily by increasing the production of insulin-like growth factor-1 (IGF-1) and its effects on cells in your body. IGF-1 is a hormone similar in structure to insulin that manages the effects of HGH in your anatomy. Insulin is an essential hormone made by your pancreas that helps control your blood sugar (glucose) levels by lowering them. Like insulin, IGF-1 has glucose-lowering effects.
Your body usually regulates your blood sugar levels carefully. You get glucose from the carbohydrates in the food you eat. This sugar is an important source of power and confers nutrients to your body’s organs, muscles, and nervous system.
Insulin is the main hormone your pancreas makes to lower blood sugar levels when they get too high, and glucagon is the main hormone your pancreas makes to raise glucose levels when they get too low.
While HGH normally raises blood sugar levels when they get too low, if you have excess amounts of HGH in your body, it can counteract the effects of insulin, causing blood sugar levels to rise.
Can HGH Make You Taller?
Human growth hormone increases vertical growth in children. However, once your growth plates are attached, HGH cannot make you taller. Instead, after you reach your final height, Human Growth Hormone helps maintain body composition and has other important effects on metabolism.
What are normal levels of human growth hormone (HGH)?
Your pituitary gland releases HGH in pulses. The size and duration of pulses vary depending on the time of day and your age and gender. Because of this, random HGH measurements are rarely useful to healthcare providers in confirming or ruling out a diagnosis. Instead, Human Growth Hormone measurement tests are most useful when measured as part of a stimulation or suppression test.
If you or your child are experiencing symptoms related to HGH deficiency or excess, contact your HGHMeds healthcare provider.
If you are receiving treatment for abnormal HGH levels, it is important to visit your provider regularly to make sure your treatment is working.
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Written by
Lavannya Banerjee (The Forbidden Fruit)
